Mirk-IN-1

Base Information

Chemical Name:Mirk-IN-1
CAS No.:1386979-55-0
Molecular Formula:C₂₃H₁₇Cl₂N₅O₄
Molecular Weight:498.325
Hs Code.:
Mol file:1386979-55-0.mol

Synonyms:2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]-amide

Suppliers and Price of Mirk-IN-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TC-S7004
5mg
$ 95.00

TRC
TC-S7004
10mg
$ 175.00

Crysdot
Mirk-IN-1 98+%
10mg
$ 111.00

Crysdot
Mirk-IN-1 98+%
50mg
$ 444.00

ChemScene
Mirk-IN-1 99.53%
50mg
$ 768.00

ChemScene
Mirk-IN-1 99.53%
10mg
$ 192.00

Total 4 raw suppliers

Chemical Property of Mirk-IN-1

Chemical Property:

PKA:10.84±0.70(Predicted)
Density:1.51±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

TC-S7004 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses TC-S 7004 is a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A/B (DYRK1A/B) inhibitor (1,2).

Technology Process of Mirk-IN-1

There total 5 articles about Mirk-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.8%

: 1386980-75-1
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid

: 4152-90-3
m-chlorobenzylamine

: 1386979-55-0
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: 4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

m-chlorobenzylamine; In N,N-dimethyl-formamide; for 24h;

Reference yield:

: 1386979-05-0
4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid methyl ester

: 1386979-55-0
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol / 18 h / 65 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 24 h

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 209849-69-4
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester

: 1386979-55-0
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [2-chloro-5-(3-chloro-benzylcarbamoyl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 18 h / 65 °C

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: sodium hydroxide; water / methanol / 18 h / 65 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 24 h

With water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;