2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1609565-33-4
Molecular Formula:C₂₃H₂₁F₂N₅O₃SSi
Molecular Weight:513.6
Hs Code.:

Synonyms:2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of 2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

There total 3 articles about 2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1609565-18-5
6-bromo-3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazine

: 1609565-33-4
2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1159977-65-7
6-bromoimidazo[1,2-b]pyridazine

: 1609565-33-4
2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / methanol / 18.5 h / -10 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water;

Reference yield:

: 1609565-17-4
6-bromo-3-iodoimidazo[1,2-b]pyridazine

: 1609565-33-4
2,4-difluoro-N-(2-methoxy-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1 h / 90 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water;