(R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE

Base Information

• Chemical Name: (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE
• CAS No.: 116041-30-6
• Molecular Formula: C12H15 N O2
• Molecular Weight: 205.25
• Hs Code.: 2933790090
• Mol file: 116041-30-6.mol

Synonyms:(R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE

Chemical Property of (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE

Chemical Property:

• PSA: 40.54000
• LogP: 1.10780

Purity/Quality:

99%min ^*data from raw suppliers

1-Benzyl-5-(hydroxymethyl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE

There total 8 articles about (R)-1-BENZYL-5-HYDROXYMETHYL-2- PYRROLIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (103301-78-6) → 5-hydroxymethyl-1-phenylmethyl-2-pyrrolidinone (116041-30-6)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 18.5h;

DOI:10.1002/chem.201701464

Reference yield:

methyl N-(2-methylphenyl)pyroglutamate → 5-hydroxymethyl-1-phenylmethyl-2-pyrrolidinone (116041-30-6)

Guidance literature:

With sodium borohydrid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol;

Reference yield:

(3R,5R)-1-Benzyl-5-hydroxymethyl-3-(toluene-4-sulfonyl)-pyrrolidin-2-one → 5-hydroxymethyl-1-phenylmethyl-2-pyrrolidinone (116041-30-6)

Guidance literature:

With sodium amalgam; sodium phosphate; In methanol; at 20 ℃; for 2h;

DOI:10.1055/s-2004-816001

upstream raw materials:

N-benzyl-2-(4-methylphenylsulfonyl)acetamide

1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

methyl 5-oxopyrrolidine-2-carboxylate

benzyl bromide

Downstream raw materials:

1-benzyl-5-hydroxymethyl-pyrrolidin-2-one methanesulphonic acid ester

1-benzyl-2-(hydroxymethyl)pyrrolidine

Refernces

• 1、 Chang, Meng-Yang,Chen, Chung-Yi,Tasi, Min-Ruey,Tseng, Tze-Wei,Chang, Nein-Chen. "New synthesis and application of 3-substituted prolinols". . p. 840 - 846. Retrieved 2007/10/03.
• 2、 -. "5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, pharmaceutical compositions and use". . . Retrieved 2008/06/13.