3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate
• CAS No.: 956139-36-9
• Molecular Formula: C₁₈H₂₁NO₈S
• Molecular Weight: 411.433
• Mol file: 956139-36-9.mol

Synonyms:3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate

Chemical Property of 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate

There total 4 articles about 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

C12H18N2O5 (956139-39-2) + p-toluenesulfonyl chloride (98-59-9) → 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate (956139-36-9)

Guidance literature:

With pyridine; Inert atmosphere;

DOI:10.1002/anie.201201690

Reference yield: 54.0%

1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol (253873-43-7) + p-toluenesulfonyl chloride (98-59-9) → 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate (956139-36-9)

Guidance literature:

With pyridine; at 20 ℃; for 5h;

DOI:10.1016/j.bioorg.2018.07.003

Reference yield:

6-nitroveratraldehyde (20357-25-9) → 3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl 4-methylbenzenesulfonate (956139-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium tetrahydroborate; methanol / 20 °C

3.1: pyridine / 5 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; sodium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1016/j.bioorg.2018.07.003

upstream raw materials:

C₁₂H₁₈N₂O₅

p-toluenesulfonyl chloride

6-nitroveratraldehyde

1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol

Downstream raw materials:

methyl 6-((3-(4,5-dimethoxy-2-nitrophenyl)-3-hydroxypropyl)(methyl)amino)-6-oxohexanoate

C₂₃H₃₀N₄O₉

1-chloro-9-(4,5-dimethoxy-2-nitrophenyl)-12-methyl-2,7,13-trioxo-8-oxa-3,6,12-triazaocta-triazaoctadecan-18-oic acid

C₂₂H₃₄N₄O₉