(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

Base Information

Chemical Name:(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea
CAS No.:1416977-85-9
Molecular Formula:C₂₁H₁₈Cl₃F₃N₂S
Molecular Weight:493.808
Hs Code.:

Synonyms:(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

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Chemical Property of (E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

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Technology Process of (E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

There total 5 articles about (E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1416980-02-3
(E)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-amine

: 556-61-6
methyl thioisocyanate

: 1416977-85-9
(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: In diethyl ether; at 25 ℃; for 2h;

Reference yield:

: 34598-49-7
5-Bromo-1-indanone

: 1416977-85-9
(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / Reflux

2: [2,2]bipyridinyl; copper(l) chloride / 1-Methylpyrrolidine / 16 h / 180 °C

3: sodium cyanoborohydride; ammonium acetate; methanol / 16 h / Reflux

4: diethyl ether / 2 h / 25 °C

With methanol; ammonium acetate; sodium cyanoborohydride; potassium carbonate; [2,2]bipyridinyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) chloride; In 1-Methylpyrrolidine; diethyl ether; toluene;

Reference yield:

: 1416979-50-4
5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene

: 1416977-85-9
(E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: [2,2]bipyridinyl; copper(l) chloride / 1-Methylpyrrolidine / 16 h / 180 °C

2: sodium cyanoborohydride; ammonium acetate; methanol / 16 h / Reflux

3: diethyl ether / 2 h / 25 °C

With methanol; ammonium acetate; sodium cyanoborohydride; [2,2]bipyridinyl; copper(l) chloride; In 1-Methylpyrrolidine; diethyl ether;