ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

Base Information

Chemical Name:ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate
CAS No.:1357576-34-1
Molecular Formula:C₃₁H₃₇ClN₂O₃S
Molecular Weight:553.165
Hs Code.:

Synonyms:ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

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Chemical Property of ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

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Technology Process of ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

There total 6 articles about ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357577-27-5
ethyl 4-(4-((4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

: 1357576-34-1
ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

: 1357576-35-2
ethyl 4-(4-((S)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

Guidance literature:: With Chiralpak AD column Column; In ethanol; carbon dioxide; Purification / work up; Resolution of diastereomers;

Reference yield:

: 137076-22-3
tert butyl 4-formylpiperidine-1-carboxylate

: 1357576-34-1
ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

: 1357576-35-2
ethyl 4-(4-((S)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 18 - 25 °C

2.1: TurboGrignard / tetrahydrofuran / 2 h / -15 °C

2.2: -15 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 5 h / 100 °C

4.1: dichloromethane / 1 h / 18 - 25 °C

5.1: caesium carbonate / ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct / ethanol / 1.5 h / 110 °C

6.1: Chiralpak AD column Column / ethanol; carbon dioxide / Resolution of diastereomers

With titanium(IV) tetraethanolate; potassium phosphate; TurboGrignard; caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; ruphos; In tetrahydrofuran; ethanol; dichloromethane; carbon dioxide; water; toluene;

Reference yield:

: 1357577-23-1
tert-butyl 4-((2-bromophenyl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidine-1-carboxylate

: 1357576-34-1
ethyl 4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

: 1357576-35-2
ethyl 4-(4-((S)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 5 h / 100 °C

2: dichloromethane / 1 h / 18 - 25 °C

3: caesium carbonate / ruphos; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct / ethanol / 1.5 h / 110 °C

4: Chiralpak AD column Column / ethanol; carbon dioxide / Resolution of diastereomers

With potassium phosphate; caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; ruphos; In ethanol; dichloromethane; carbon dioxide; water; toluene;