(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

Base Information

Chemical Name:(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal
CAS No.:957782-32-0
Molecular Formula:C₂₄H₄₂O₄Si
Molecular Weight:422.681
Hs Code.:

Synonyms:(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

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Chemical Property of (2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

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Technology Process of (2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

There total 4 articles about (2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 957782-31-9
(2R,3R,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptan-1-ol

: 957782-32-0
(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo701524p

Reference yield:

: C₂₄H₄₂O₄Si

: 957782-32-0
(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

Guidance literature:: Multi-step reaction with 2 steps

1: 0.591 g / DIBAL-H / CH₂Cl₂; toluene / -78 - 20 °C

2: 84 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; diisobutylaluminium hydride; Dess-Martin periodane; In dichloromethane; toluene; 2: Dess-Martin oxidation;
DOI:10.1021/jo701524p

Reference yield:

: (2S)-2-((2R,4R,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)-4-methylpentan-3-ol

: 957782-32-0
(2S,3S,4R,5S)-5-(tert-butyldimethylsilyloxy)-3-(4-methoxybenzyloxy)-2,4,6-trimethylheptanal

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / CH₂Cl₂ / -78 - 20 °C

2: 0.591 g / DIBAL-H / CH₂Cl₂; toluene / -78 - 20 °C

3: 84 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; 2,6-dimethylpyridine; diisobutylaluminium hydride; Dess-Martin periodane; In dichloromethane; toluene; 3: Dess-Martin oxidation;
DOI:10.1021/jo701524p