(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

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Chemical Name:(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide
CAS No.:1289627-73-1
Molecular Formula:C₂₈H₃₇NO₇S
Molecular Weight:531.67
Hs Code.:

Synonyms:(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

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Chemical Property of (2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

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Technology Process of (2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

There total 4 articles about (2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.4%

: 36603-49-3
4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

: 1289626-41-0
(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanamide

: 1289627-73-1
(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

Guidance literature:: With potassium carbonate; Pd (II) EnCatBINAP 30; In 1,4-dioxane; water; at 90 ℃;

Reference yield:

: 1289626-32-9
(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid

: 1289627-73-1
(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 100 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

3: potassium carbonate / ethanol; water / 70 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; 3: Suzuki-Miyaura coupling;
DOI:10.1021/jm2014748

Reference yield:

: 1289626-39-6
(2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoic acid

: 1289627-73-1
(2R)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)-4-[4'-(tetrahydro-2H-pyran-2-yloxy)biphenyl-4-yl]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

2: potassium carbonate / ethanol; water / 70 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; water; 2: Suzuki-Miyaura coupling;
DOI:10.1021/jm2014748