N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Base Information

Chemical Name:N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide
CAS No.:1287791-99-4
Molecular Formula:C₂₂H₁₇NO₂S₂
Molecular Weight:391.514
Hs Code.:

Synonyms:N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

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Chemical Property of N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

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Technology Process of N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

There total 2 articles about N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67237-53-0
3-ethynylthiophene

: 1287791-77-8
N-(2,3-dichlorophenyl)-2-hydroxy-2-methylpropanamide

: 1287791-99-4
N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: N-(2,3-dichlorophenyl)-2-hydroxy-2-methylpropanamide; With dichloro bis(acetonitrile) palladium(II); caesium carbonate; XPhos; In acetonitrile; at 20 ℃; for 0.416667h; Inert atmosphere;

3-ethynylthiophene; In acetonitrile; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo200406f

Reference yield:

: 1226261-49-9
2-(2,3-dichlorophenoxy)-2-methylpropanamide

: 1287791-99-4
N-(2,3-bis(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

2.1: dichloro bis(acetonitrile) palladium(II); caesium carbonate; XPhos / acetonitrile / 0.42 h / 20 °C / Inert atmosphere

2.2: 12 h / 80 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); caesium carbonate; sodium hydroxide; XPhos; In N,N-dimethyl-formamide; acetonitrile; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1021/jo200406f