methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

Base Information

Chemical Name:methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate
CAS No.:1445597-07-8
Molecular Formula:C₁₄H₁₅F₃N₂O₇
Molecular Weight:380.278
Hs Code.:

Synonyms:methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

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Chemical Property of methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

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Technology Process of methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

There total 4 articles about methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1445597-06-7
methyl 3-(3,4-dimethoxyphenyl)-3-(2,2,2-trifluoroacetamido)propanoate

: 1445597-07-8
methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

Guidance literature:: With nitric acid; for 2h; Cooling with ice; Darkness;
DOI:10.1055/s-0032-1318314

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1445597-07-8
methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / ethanol / 18 h / Reflux

2: methanol / 3 h / Reflux

3: pyridine / 1 h / 0 °C

4: nitric acid / 2 h / Cooling with ice; Darkness

With pyridine; ammonium acetate; nitric acid; In methanol; ethanol;
DOI:10.1055/s-0032-1318314

Reference yield:

: 34840-85-2,54160-62-2,34841-09-3,54160-63-3
3-amino-3-(3,4-dimethoxyphenyl)propanoic acid

: 1445597-07-8
methyl 3-(4,5-dimethoxy-2-nitrophenyl)-3-(2,2,2-trifluoroacetamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 3 h / Reflux

2: pyridine / 1 h / 0 °C

3: nitric acid / 2 h / Cooling with ice; Darkness

With pyridine; nitric acid; In methanol;
DOI:10.1055/s-0032-1318314