2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Base Information

Chemical Name:2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid
CAS No.:287120-00-7
Molecular Formula:C₁₈H₁₈N₂O₈S
Molecular Weight:422.416
Hs Code.:

Synonyms:2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

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Chemical Property of 2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

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Technology Process of 2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

There total 12 articles about 2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 287119-96-4
methyl 2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

: 287120-00-7
2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: With sodium hydroxide; water; In methanol; at 20 ℃;
DOI:10.1039/b000135j

Reference yield:

: 51794-07-1
2-hydroxy-5-nitrophenylacetic acid

: 287120-00-7
2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 89 percent / conc. H₂SO₄ / 16 h / Heating

2: 82 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

3: 88 percent / 1,2-dichloro-benzene / 3 h / 180 °C

4: KOH; H₂O / methanol / 2 h / Heating

5: 0.81 g / 1 h / 20 °C

6: 96 percent / MCPBA / CH₂Cl₂ / 2 h / 20 °C

7: H₂ / Pd/C / ethanol / 3102.97 Torr

8: tetrahydrofuran / -20 °C

9: BH₃*DMS / tetrahydrofuran / 20 °C

10: 45 percent / tetrahydrofuran / 20 °C

11: 81 percent / NaOH; H₂O / methanol / 20 °C

With potassium hydroxide; sodium hydroxide; dimethylsulfide borane complex; sulfuric acid; water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-benzene; 1: Esterification / 2: Substitution / 3: Rearrangement / 4: Hydrolysis / 5: Methylation / 6: Oxidation / 7: Reduction / 8: Formylation / 9: Reduction / 10: Acylation / 11: Hydrolysis;
DOI:10.1039/b000135j

Reference yield:

: 155388-58-2
2-hydroxy-5-nitrophenylacetic acid methyl ester

: 287120-00-7
2-methylsulfonyl-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

2: 88 percent / 1,2-dichloro-benzene / 3 h / 180 °C

3: KOH; H₂O / methanol / 2 h / Heating

4: 0.81 g / 1 h / 20 °C

5: 96 percent / MCPBA / CH₂Cl₂ / 2 h / 20 °C

6: H₂ / Pd/C / ethanol / 3102.97 Torr

7: tetrahydrofuran / -20 °C

8: BH₃*DMS / tetrahydrofuran / 20 °C

9: 45 percent / tetrahydrofuran / 20 °C

10: 81 percent / NaOH; H₂O / methanol / 20 °C

With potassium hydroxide; sodium hydroxide; dimethylsulfide borane complex; water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-benzene; 1: Substitution / 2: Rearrangement / 3: Hydrolysis / 4: Methylation / 5: Oxidation / 6: Reduction / 7: Formylation / 8: Reduction / 9: Acylation / 10: Hydrolysis;
DOI:10.1039/b000135j