Technology Process of 1-Cyclohexylamino-4,5,6,7,9,10-hexahydro-8H-azepino[3,2,1-hi]indol-2-one
There total 5 articles about 1-Cyclohexylamino-4,5,6,7,9,10-hexahydro-8H-azepino[3,2,1-hi]indol-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ethylmagnesium bromide;
In
tetrahydrofuran; diethylene glycol dimethyl ether;
1.) 0 deg C, 30 min, 2.) 120 deg C, 30 min;
DOI:10.1021/jo980916c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Et3N, 2.) diphenyl phosphoroazidate / 1.) C6H6, room temperature, 30 min, 2.) 0 deg C, 30 min
2: acetonitrile / 0.67 h / Heating
3: Ambient temperature
4: 56 percent / NaH / dimethylformamide / Ambient temperature
5: 70 percent / EtMgBr / bis-(2-methoxy-ethyl) ether; tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 120 deg C, 30 min
With
diphenyl phosphoryl azide; ethylmagnesium bromide; sodium hydride; triethylamine;
In
tetrahydrofuran; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo980916c
- Guidance literature:
-
Multi-step reaction with 3 steps
1: Ambient temperature
2: 56 percent / NaH / dimethylformamide / Ambient temperature
3: 70 percent / EtMgBr / bis-(2-methoxy-ethyl) ether; tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 120 deg C, 30 min
With
ethylmagnesium bromide; sodium hydride;
In
tetrahydrofuran; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo980916c
