(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

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Chemical Name:(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester
CAS No.:564489-36-7
Molecular Formula:C₃₅H₅₄N₆O₈S
Molecular Weight:718.915
Hs Code.:

(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

Synonyms:(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

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Chemical Property of (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

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Technology Process of (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

There total 14 articles about (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 340270-75-9
2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

: 564489-36-7
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: With Cd/Pb; ammonium acetate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(01)00194-0

Reference yield:

: 34290-59-0
(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

: 564489-36-7
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 90 percent / imidazole / dimethylformamide / 3 h / 20 °C

2: 92 percent / Lawesson's reagent / benzene / 2 h / Heating

3: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.83 h / 20 °C

4: acetyl chloride / methanol / 3 h / 20 °C

5: diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 63 h / 0 - 20 °C

6: acetyl chloride / methanol / 7 h / 20 °C

7: 1.85 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 24 h / 0 - 20 °C

8: acetyl chloride / methanol / 11 h / 20 °C

9: 80 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

10: acetyl chloride / methanol / 3.5 h / 20 °C

11: 249 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 h / 0 - 20 °C

12: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.5 h / 20 °C

With Lawessons reagent; 1H-imidazole; Cd/Pb; ammonium acetate; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

: 142342-82-3
(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

: 564489-36-7
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: acetyl chloride / methanol / 3 h / 20 °C

2: diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 63 h / 0 - 20 °C

3: acetyl chloride / methanol / 7 h / 20 °C

4: 1.85 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 24 h / 0 - 20 °C

5: acetyl chloride / methanol / 11 h / 20 °C

6: 80 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

7: acetyl chloride / methanol / 3.5 h / 20 °C

8: 249 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 23 h / 0 - 20 °C

9: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 0.5 h / 20 °C

With Cd/Pb; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00294-1