(5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one

Base Information

• Chemical Name: (5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one
• CAS No.: 768370-31-6
• Molecular Formula: C₂₇H₃₀N₂O
• Molecular Weight: 398.548
• Mol file: 768370-31-6.mol

Synonyms:(5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one

Chemical Property of (5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one

There total 1 articles about (5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzylamine (100-46-9) + (5R)-1-[(1S)-1-(1-naphthyl)ethyl]-1-azaspiro[4.4]nonane-2,6-dione (502622-13-1) → (5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one (768370-31-6)

Guidance literature:

benzylamine; (5R)-1-[(1S)-1-(1-naphthyl)ethyl]-1-azaspiro[4.4]nonane-2,6-dione; With toluene-4-sulfonic acid; In toluene; for 16h; Heating;

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1016/j.tetasy.2004.06.011

Reference yield:

(5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one (768370-31-6) → (1R,6'R,1''R)-{[1-(1-naphthalen-2-ylethyl)-2-oxo-1-azaspiro[4.4]non-6-ylcarbamoyl]phenylmethyl}carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 840 mg / H₂ / Pd/C / methanol / 72 h / 760 Torr

2: 91 percent / DCC / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.tetasy.2004.06.011

Reference yield:

(5R,6R,1'S)-6-benzylamino-1-[1-(naphthalen-1-yl)ethyl]-1-azaspiro[4.4]nonan-2-one (768370-31-6) → (1S,6'R,1''R)-{[1-(1-naphthalen-2-ylethyl)-2-oxo-1-azaspiro[4.4]non-6-ylcarbamoyl]phenylmethyl}carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 840 mg / H₂ / Pd/C / methanol / 72 h / 760 Torr

2: 100 percent / DCC / CH₂Cl₂ / 1.5 h / 20 °C

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.tetasy.2004.06.011

upstream raw materials:

benzylamine

(5R)-1-[(1S)-1-(1-naphthyl)ethyl]-1-azaspiro[4.4]nonane-2,6-dione