1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

Base Information

Chemical Name:1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine
CAS No.:1494683-29-2
Molecular Formula:C₄₂H₄₄NO₂P
Molecular Weight:625.791
Hs Code.:

Synonyms:1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

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Chemical Property of 1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

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Technology Process of 1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

There total 5 articles about 1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3082-62-0
(1S)-1-(2-naphthyl)ethylamine

: 1494683-29-2
1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) isopropylate / ethyl acetate / 1 h / 20 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 1 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 0.08 h / -78 °C / Inert atmosphere

4.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 0.5 h / -78 - 20 °C / Inert atmosphere

With titanium(IV) isopropylate; n-butyllithium; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; hexane; ethyl acetate;
DOI:10.1002/ejoc.201300729

Reference yield:

: 1,1-dichloro-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphanamine

: 14804-38-7
5-bromo-2-methoxy-1,3-dimethylbenzene

: 1494683-29-2
1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

Guidance literature:: 5-bromo-2-methoxy-1,3-dimethylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

1,1-dichloro-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphanamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/ejoc.201300729

Reference yield:

: 357958-94-2
(S)-bis((S)-1-(naphthalen-2-yl)ethyl)amine

: 1494683-29-2
1,1-bis(3,5-dimethoxyphenyl)-N,N-bis((S)-1-(naphthalen-2-yl)ethyl)phosphinamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 0.08 h / -78 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1002/ejoc.201300729