methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

Base Information

Chemical Name:methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate
CAS No.:484024-20-6
Molecular Formula:C₃₇H₅₆N₆O₁₀
Molecular Weight:744.886
Hs Code.:

Synonyms:methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

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Chemical Property of methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

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Technology Process of methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

There total 8 articles about methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 484024-16-0
methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(tert-butoxycarbonyl)aminobutyl]-4,7,10-trioxoundecanoate

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: 484024-20-6
methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

Guidance literature:: With triethylamine; In dichloromethane; for 16h;

Reference yield: 61.0%

: C₂₆H₃₈N₄O₆*C₂HF₃O₂

: 207857-15-6
1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

: 484024-20-6
methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Sealed tube; Inert atmosphere;
DOI:10.1039/c6ob00950f

Reference yield:

: 840-97-1
N-acetyl-L-tyrosine ethyl ester

: 484024-20-6
methyl (2S,5S,8S)-2-allyl-8-(4-allyloxybenzyl)-3,6,9-triaza-5-[4-(N,N-di-tert-butoxycarbonyl)guanidinobutyl]-4,7,10-trioxoundecanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Sealed tube; Inert atmosphere

1.2: 12 h / 20 °C / Sealed tube; Inert atmosphere

2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Sealed tube; Inert atmosphere

4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Sealed tube; Inert atmosphere

6.1: 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 3 h / 20 °C

7.1: triethylamine / dichloromethane / 3 h / 20 °C / Sealed tube; Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;
DOI:10.1039/c6ob00950f