N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

Base Information

Chemical Name:N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine
CAS No.:1141472-96-9
Molecular Formula:C₂₆H₂₂FN₃O₅
Molecular Weight:475.476
Hs Code.:

Synonyms:N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

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Chemical Property of N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

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Technology Process of N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

There total 13 articles about N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1141472-94-7
methyl N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycinate

: 1141472-96-9
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1002/cmdc.201402557

Reference yield:

: 1141471-95-5
2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoic acid

: 1141472-96-9
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201402557

Reference yield:

: 148547-19-7
4-Bromo-3-methylbenzoic acid methyl ester

: 1141472-96-9
N-(2-fluoro-4-{5-[2-(methoxymethyl)-2’-methylbiphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzoyl)glycine

Guidance literature:: Multi-step reaction with 10 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 48 h / 70 °C / Inert atmosphere

2: 96 h / Reflux

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 1 h / 110 °C / Inert atmosphere

4: sodium hydroxide / ethanol / 1 h / 60 °C

5: oxalyl dichloride / toluene; N,N-dimethyl-formamide / 3 h / 20 °C

6: pyridine / toluene / 36 h / 20 °C / Inert atmosphere; Reflux

7: sodium hydroxide / methanol; tetrahydrofuran / 12 h / 20 °C

8: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

9: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

10: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/cmdc.201402557