(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

Base Information

Chemical Name:(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime
CAS No.:1072709-27-3
Molecular Formula:C₂₃H₂₂N₂O₅
Molecular Weight:406.438
Hs Code.:

Synonyms:(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

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Chemical Property of (E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

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Technology Process of (E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

There total 10 articles about (E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1072708-45-2
(E)-5'-hydroxy-2'-iodo-4'-methoxyacetophenone O-4-nitrobenzyl oxime

: 5720-05-8
4-methylphenylboronic acid

: 1072708-42-9
(E)-3'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime

: 1072709-27-3
(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 110 ℃; for 0.5h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 30777-85-6
N-phthalimido-O-(p-nitrobenzyl)-hydroxylamine

: 1072708-42-9
(E)-3'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime

: 1072709-27-3
(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / ethanol / 3 h / Heating / reflux

2: pyridine / ethanol / 3 h / Heating / reflux

3: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 0.5 h / 110 °C / Microwave irradiation

With pyridine; hydrogenchloride; tetrabutylammomium bromide; water; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene;

Reference yield:

: 621-59-0
isovanillin

: 1072708-42-9
(E)-3'-hydroxy-4'-methoxyacetophenone O-4-nitrobenzyl oxime

: 1072709-27-3
(E)-5'-hydroxy-4'-methoxy-2'-(4-methylphenyl)acetophenone O-4-nitrobenzyloxime

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 42 h / 18 °C

2.1: silver trifluoroacetate / chloroform / Heating / reflux

2.2: 3.25 h / Heating / reflux

3.1: magnesium / diethyl ether / 0.5 h / 0 °C

3.2: 1 h / 0 - 18 °C

4.1: manganese(IV) oxide / chloroform / 21 h / Heating / reflux

5.1: aluminum (III) chloride / dichloromethane / 21 h / 18 °C

6.1: pyridine / ethanol / 3 h / Heating / reflux

7.1: tetrabutylammomium bromide; potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 0.5 h / 110 °C / Microwave irradiation

With pyridine; manganese(IV) oxide; aluminum (III) chloride; tetrabutylammomium bromide; silver trifluoroacetate; potassium carbonate; magnesium; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;