(2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide

Base Information

• Chemical Name: (2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide
• CAS No.: 711020-29-0
• Molecular Formula: C₁₄H₁₇Cl₂NO₂
• Molecular Weight: 302.2

Synonyms:(2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide

Chemical Property of (2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide

Chemical Property:

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Technology Process of (2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide

There total 1 articles about (2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(S)-Alaninol (2749-11-3) + (2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid (147643-57-0) → (2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide (711020-29-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; Heating;

DOI:10.1016/j.bmc.2004.03.015

Reference yield:

(2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide (711020-29-0) → (2S)-2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}propan-1-ol (711020-33-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; Heating;

DOI:10.1016/j.bmc.2004.03.015

Reference yield:

(2S)-2-(3,4-dichlorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]pent-4-enamide (711020-29-0) → tert-butyl [(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl][(1S)-2-hydroxy-1-methylethyl]carbamate (711020-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminum hydride / diethyl ether; tetrahydrofuran / Heating

2: sodium carbonate / dioxane; H₂O

With lithium aluminium tetrahydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water;

DOI:10.1016/j.bmc.2004.03.015

upstream raw materials:

(S)-Alaninol

(2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid

Downstream raw materials:

(2S)-2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}propan-1-ol

tert-butyl [(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl][(1S)-2-hydroxy-1-methylethyl]carbamate

2-[(2S)-2-(3,4-dichlorophenyl)-4-oxobutyl]-3-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocine-7-carbonitrile

(3S)-2-[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]-3-methyl-1-oxo-1,3,4,6-tetrahydro-2H-naphtho[1,2-f][1,4]oxazocine-7-carbonitrile

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