S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Base Information

Chemical Name:S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate
CAS No.:1429397-11-4
Molecular Formula:C₃₁H₃₁FN₆O₄S₂
Molecular Weight:634.755
Hs Code.:

Synonyms:S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Suppliers and Price of S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

There total 3 articles about S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190-93-8
(Acetylthio)acetic acid

: 1341216-05-4
1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

: 1429397-11-4
S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Guidance literature:: (Acetylthio)acetic acid; 1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea; With triethylamine; In N,N-dimethyl-formamide; for 2h; Sonication; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

: 1341216-04-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

: 1429397-11-4
S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 2 h / Sonication; Inert atmosphere

2.2: 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429397-11-4
S-(2-(4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl) ethanethioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.25 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 2 h / Sonication; Inert atmosphere

3.2: 20 °C / Inert atmosphere

With acetic acid; triethylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;