2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

Base Information

Chemical Name:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole
CAS No.:745794-63-2
Molecular Formula:C₃₂H₃₅N₃O₇S
Molecular Weight:605.712
Hs Code.:

Synonyms:2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

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Chemical Property of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

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Technology Process of 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

There total 5 articles about 2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 49787-02-2
4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol

: 745794-62-1
2-O-[4'-(2''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-mannitole

: 745794-63-2
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 40 ℃;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 745794-63-2
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 80 °C

1.2: 65 percent / TBAI / dimethylformamide / 18 h / 40 °C

2.1: 21 percent / PPh₃; Ba(OH)2*8H₂O / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 15 h / Heating

3.1: 57 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With barium dihydroxide; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 2.1: Suzuki coupling / 3.1: Mitsunobu reaction;

Reference yield:

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 745794-63-2
2-O-[4'-(5''-methyl[1,2,4]oxadiazol-3''-yl)phenyl]-5-O-[4'''-(2''''-tert-butylaminosulfonylphenyl)benzyl]-1,4:3,6-dianhydro-D-sorbitole

Guidance literature:: Multi-step reaction with 2 steps

1: 21 percent / PPh₃; Ba(OH)2*8H₂O / Pd₂(dba)3 / 1,2-dimethoxy-ethane / 15 h / Heating

2: 57 percent / PPh₃; diisopropyl azodicarboxylate / tetrahydrofuran / 40 °C

With barium dihydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling / 2: Mitsunobu reaction;