3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

Base Information

Chemical Name:3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid
CAS No.:1415571-94-6
Molecular Formula:C₂₅H₂₁F₃N₄O₃
Molecular Weight:482.462
Hs Code.:

Synonyms:3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

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Chemical Property of 3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

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Technology Process of 3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

There total 2 articles about 3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415571-93-5
methyl 3-[(1-{5[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoate

: 1415571-94-6
3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

Guidance literature:: methyl 3-[(1-{5[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 40 ℃;

With trifluoroacetic acid; In water;

Reference yield:

: 1356385-98-2
2-(6-fluoropyridin-3-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

: 1415571-94-6
3-[(1-{5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane

1.2: 1 h / 160 °C / microwave irradiation

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 40 °C

With lithium hydroxide monohydrate; water; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;