β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

Base Information

Chemical Name:β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester
CAS No.:137586-43-7
Molecular Formula:C₂₆H₂₉FO₄
Molecular Weight:424.512
Hs Code.:

Synonyms:β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

Suppliers and Price of β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

There total 3 articles about β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 137586-43-7
β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

With piperidine; acetic acid; lithium hexamethyldisilazane; In benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 137586-43-7
β-(4-Fluorophenyl)-6,7,8,9-tetrahydro-α-(2-methyl-1-oxopropyl)-5-oxo-5H-benzocycloheptene-6-propanoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

With piperidine; acetic acid; lithium hexamethyldisilazane; In benzene;
DOI:10.1021/jm00113a019