3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

Base Information

Chemical Name:3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide
CAS No.:607713-59-7
Molecular Formula:C₁₆H₁₇N₅OS
Molecular Weight:327.41
Hs Code.:

Synonyms:3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

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Chemical Property of 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

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Technology Process of 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

There total 7 articles about 3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866582-35-6
3-[4-amino-5-(4-nitro-phenyl)-thieno[2,3-d]pyrimidin-6-yl]-N-methyl-propionamide

: 607713-59-7
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; at 80 ℃; for 2h;
DOI:10.1021/jm050458h

Reference yield:

: 607713-80-4
6,6-dicyano-5-phenylhex-5-enoic acid

: 607713-59-7
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / HOBt; EDC; NMM / dimethylformamide / 20 °C

2: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

3: 17 h / 155 °C

4: H₂SO₄; HNO₃ / 1.75 h / 0 - 20 °C

5: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

With 4-methyl-morpholine; sulfuric acid; nitric acid; iron; ammonium chloride; benzotriazol-1-ol; sulfur; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 2: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 866581-23-9
6,6-dicyano-5-phenylhex-5-enoic acid methylamide

: 607713-59-7
3-[4-amino-5-(4-aminophenyl)thieno[2,3-d]pyrimidin-6-yl]-N-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2: 17 h / 155 °C

3: H₂SO₄; HNO₃ / 1.75 h / 0 - 20 °C

4: Fe; aq. NH₄Cl / ethanol; tetrahydrofuran / 2 h / 80 °C

With sulfuric acid; nitric acid; iron; ammonium chloride; sulfur; diethylamine; In tetrahydrofuran; ethanol; 1: Gewald reaction;
DOI:10.1021/jm050458h