1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

Base Information

Chemical Name:1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine
CAS No.:128115-07-1
Molecular Formula:C₂₃H₂₀FN₃O₅
Molecular Weight:437.427
Hs Code.:

1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N<sup>4</sup>-benzoylcytosine

Synonyms:1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

Suppliers and Price of 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

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Technology Process of 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

There total 6 articles about 1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 128115-06-0
1-<5-O-benzoyl-2-deoxy-2-fluoro-3-O-<(imidazol-1-yl)thiocarbonyl>-β-D-arabinofuranosyl>-N⁴-benzoylcytosine

: 128115-07-1
1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1h; Heating;
DOI:10.1021/jm00170a016

Reference yield: 70.0%

: Benzoic acid (2R,3R,4S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-3-phenoxythiocarbonyloxy-tetrahydro-furan-2-ylmethyl ester

: 128115-07-1
1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 75 ℃;
DOI:10.1021/jm00128a013

Reference yield:

: 69123-90-6
fiacitabine

: 128115-07-1
1-(5-O-benzoyl-2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl-N⁴-benzoylcytosine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / H₂, conc. aq. NH₄OH / 10percent Pd/C / ethanol / 2 h / 1034.3 Torr

2: 72 percent / pyridine / 0.5 h / Ambient temperature

3: 78 percent / dimethylformamide / Ambient temperature

4: 87 percent / n-Bu₃SnH, AIBN / toluene / 1 h / Heating

With pyridine; ammonium hydroxide; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00170a016