N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

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Chemical Name:N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide
CAS No.:109522-83-0
Molecular Formula:C₂₀H₂₉F₂N₃O₃
Molecular Weight:397.465
Hs Code.:

Synonyms:N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

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Technology Process of N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

There total 6 articles about N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

: 109522-76-1
2-<<<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 109522-83-0
N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 760 Torr;
DOI:10.1021/ja00191a039

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 109522-83-0
N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -20 deg C, 15 min; 2.) -40 deg C -> room temp.

2: 100 percent / 1.) oxalyl chloride, DMSO; 2.) diisopropylethylamine / CH₂Cl₂ / 1.) -25 deg C, 1 h; 2.) -40 deg C -> room temp.

3: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

4: 86.2 percent / ethanol / 1.) 4 h, reflux; 2.) room temp., 48 h,

5: 86.6 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

With 4-methyl-morpholine; oxalyl dichloride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; zinc; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja00191a039

Reference yield:

: 109522-66-9
*,R^*)>-2-<<<1-Formyl-2-methylpropyl>amino>carbonyl>-1-pyrrolidinecarboxylic acid phenylmethyl ester

: 109522-83-0
N-<3,3-Difluoro-2-hydroxy-1-(1-methylethyl)-4-oxo-4-<(2-phenylethyl)amino>butyl>-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 39.2 percent / Zn / tetrahydrofuran / 4 h / Heating

2: 86.2 percent / ethanol / 1.) 4 h, reflux; 2.) room temp., 48 h,

3: 86.6 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

With hydrogen; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/ja00191a039