butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

Base Information

Chemical Name:butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate
CAS No.:1352965-66-2
Molecular Formula:C₂₀H₂₄N₂O₄S
Molecular Weight:388.488
Hs Code.:

Synonyms:butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

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Chemical Property of butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

Chemical Property:

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Technology Process of butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

There total 3 articles about butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 1352966-03-0
N-methyl-N-(4-methylphenyl)pyridine-2-sulfonamide

: 1352965-66-2
butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

Guidance literature:: With palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In 1,1-dichloroethane; at 110 ℃; for 18h; regiospecific reaction; Inert atmosphere;
DOI:10.1002/anie.201105611

Reference yield:

: 2637-34-5,73018-10-7
2-Sulfanylpyridine

: 1352965-66-2
butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hypochlorite; sulfuric acid / water / 0.25 h / 0 °C

2: pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate / 1,1-dichloroethane / 18 h / 110 °C / Inert atmosphere

With pyridine; sodium hypochlorite; sulfuric acid; palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In tetrahydrofuran; 1,1-dichloroethane; water; 3: Fujiwara-Moritani reaction;
DOI:10.1002/anie.201105611

Reference yield:

: 66715-65-9
pyridine-2-sulfonyl chloride

: 1352965-66-2
butyl (E)-3-{5-methyl-2-[N-methyl-N-(2-pyridylsulfonyl)amino]phenyl}acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate / 1,1-dichloroethane / 18 h / 110 °C / Inert atmosphere

With pyridine; palladium diacetate; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In tetrahydrofuran; 1,1-dichloroethane; 2: Fujiwara-Moritani reaction;
DOI:10.1002/anie.201105611