ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate

Base Information

• Chemical Name: ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate
• CAS No.: 726191-17-9
• Molecular Formula: C₁₈H₂₄BrClN₂O₆
• Molecular Weight: 479.755

Synonyms:ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate

Chemical Property of ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate

Chemical Property:

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Technology Process of ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate

There total 2 articles about ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl (3R)-3-amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propanoate hydrochloride + tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate (3392-07-2) → ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate (726191-17-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2007.03.034

Reference yield:

BrClC6H2OHCH(CH2COOC2H5)NH2*CH3C6H4SO3H + tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate (3392-07-2) → ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate (726191-17-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2007.03.034

Reference yield: 96.0%

ethyl (3R)-3-(N-Boc-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate (726191-17-9) → ethyl (3R)-3-(N-Gly)amino-3-(5-bromo-3-chloro-2-hydroxyphenyl)propionate hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; for 6h; Heating;

DOI:10.1016/j.bmc.2007.03.034

upstream raw materials:

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}carbamate

Downstream raw materials:

C₂₂H₂₃N₅O₇ClBrC₂H₄

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