2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine

Base Information

• Chemical Name: 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine
• CAS No.: 160963-11-1
• Molecular Formula: C₂₆H₂₈Cl₂N₄OSSi
• Molecular Weight: 543.592
• Mol file: 160963-11-1.mol

Synonyms:2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine

Chemical Property of 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine

There total 1 articles about 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6 dichloropurine (5451-40-1) + 1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-L-ribofuranose (189998-53-6) → 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine (160963-11-1) + 2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine (173009-34-2)

Guidance literature:

With ethylaluminum dichloride; sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) MeCN, 60-75 deg C, 2 h, 2.) toluene, rom temperature, overnight;

DOI:10.1080/15257779508009755

Reference yield: 77.0%

2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine (160963-11-1) → 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine (173009-37-5)

Guidance literature:

With methanol; ammonia; at 80 ℃; for 72h;

DOI:10.1080/15257779508009755

upstream raw materials:

2,6 dichloropurine

1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-L-ribofuranose

Downstream raw materials:

2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-β-L-ribofuranosyl>purine