(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

Base Information

Chemical Name:(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester
CAS No.:920266-25-7
Molecular Formula:C₄₁H₅₂O₆Si
Molecular Weight:668.946
Hs Code.:

Synonyms:(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

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Chemical Property of (4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

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Technology Process of (4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

There total 3 articles about (4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 79-22-1
methyl chloroformate

: 374686-17-6
Triethyl-((1S,2R,3S,4R)-2,3,4-tris-benzyloxy-1-but-3-enyl-1-ethynyl-hex-5-enyloxy)-silane

: 920266-25-7
(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

Guidance literature:: Triethyl-((1S,2R,3S,4R)-2,3,4-tris-benzyloxy-1-but-3-enyl-1-ethynyl-hex-5-enyloxy)-silane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h;
DOI:10.1016/j.jorganchem.2006.07.014

Reference yield:

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 920266-25-7
(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 96 percent / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.jorganchem.2006.07.014

Reference yield:

: 374686-15-4
(5S,6R,7S,8R)-6,7,8-Tris-benzyloxy-5-ethynyl-deca-1,9-dien-5-ol

: 920266-25-7
(4S,5R,6S,7R)-5,6,7-Tris-benzyloxy-4-but-3-enyl-4-triethylsilanyloxy-non-8-en-2-ynoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 96 percent / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.jorganchem.2006.07.014