5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: 5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester
• CAS No.: 394251-31-1
• Molecular Formula: C₂₆H₂₂N₂O₃
• Molecular Weight: 410.472

Synonyms:5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester

Chemical Property of 5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester

Chemical Property:

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Technology Process of 5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester

There total 1 articles about 5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (105228-46-4,335159-14-3) + cyanomethylene triphenylphosphorane (16640-68-9) → 5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester (394251-31-1)

Guidance literature:

In xylene; at 210 ℃; for 2.5h;

DOI:10.1021/ol016959o

Reference yield:

5R,6S-2-cyanomethyl-5,6-diphenyl-5,6-dihydro-[1,4]oxazine-4-carboxylic acid benzyl ester (394251-31-1) → 2R,5R,6S-2-(5,6-diphenylmorpholin-2-yl)-ethylamine dihydrochloride

Guidance literature:

With hydrogenchloride; hydrogen; palladium dichloride; In methanol; at 20 ℃; for 72h; under 6205.94 Torr;

DOI:10.1021/ol016959o

upstream raw materials:

(5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

cyanomethylene triphenylphosphorane

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