(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

Base Information

Chemical Name:(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate
CAS No.:468071-45-6
Molecular Formula:C₁₈H₂₅NO₂
Molecular Weight:287.402
Hs Code.:

Synonyms:(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

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Technology Process of (2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

There total 6 articles about (2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 164660-17-7
(3R,4E,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-hept-4-enoate

: 468071-45-6
(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 18h; Heating;
DOI:10.1055/s-2002-32580

Reference yield: 76.0%

: 569679-82-9
(3R,αS)-tert-butyl 3-(N-allyl-N-α-methylbenzylamino)-pent-4-enoate

: 468071-45-6
(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 12h; Heating;
DOI:10.1016/S0040-4020(03)00411-3

Reference yield:

: 81838-85-9
tert-butyl (2E,4E)-2,4-hexadienoate

: 468071-45-6
(2R,αS)-tert-butyl 1-(N-α-methylbenzyl)-2,5-dihydro-1H-2-pyrrolyl-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / n-butyllithium / tetrahydrofuran / -78 °C

2: 77 percent / PhCH=Ru(PCy₃)2Cl₂ / CH₂Cl₂ / 12 h / Heating

With n-butyllithium; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(03)00411-3