2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

Base Information

Chemical Name:2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester
CAS No.:1429310-00-8
Molecular Formula:C₃₈H₃₀N₂O₄
Molecular Weight:578.667
Hs Code.:

Synonyms:2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

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Chemical Property of 2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

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Technology Process of 2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

There total 10 articles about 2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₃₀N₂O₄

: C₃₈H₃₀N₂O₄

: 1429309-99-8
2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

: 1429310-00-8
2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

Guidance literature:: With Chiralcel OG column; In ethanol; hexane; at 20 ℃; Resolution of racemate;
DOI:10.1016/j.bmcl.2013.02.013

Reference yield:

: 184000-11-1
{4-[(benzyloxy)carbonyl]phenyl}boronic acid

: 1429310-00-8
2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(o-tolyl)phosphine; sodium hydrogencarbonate / water; 1,2-dimethoxyethane / 0.25 h / Inert atmosphere

1.2: 2 h / 90 °C / Inert atmosphere

1.3: 1 h / 20 °C

2.1: zinc(II) chloride / toluene / Dean-Stark

3.1: indium(III) triflate / acetonitrile / 5 h / Reflux; Molecular sieve

4.1: Chiralcel OG column / ethanol; hexane / 20 °C / Resolution of racemate

With indium(III) triflate; sodium hydrogencarbonate; tris-(o-tolyl)phosphine; zinc(II) chloride; In 1,2-dimethoxyethane; ethanol; hexane; water; toluene; acetonitrile; 1.1: |Suzuki-Miyaura Coupling / 1.2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.02.013

Reference yield:

: C₂₉H₂₂N₂O₄

: 1429310-00-8
2'-(2-cyano-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: indium(III) triflate / acetonitrile / 5 h / Reflux; Molecular sieve

2: Chiralcel OG column / ethanol; hexane / 20 °C / Resolution of racemate

With indium(III) triflate; In ethanol; hexane; acetonitrile;
DOI:10.1016/j.bmcl.2013.02.013