5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI)

Base Information

• Chemical Name: 5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI)
• CAS No.: 115012-09-4
• Molecular Formula: C7H6 N2 O2
• Molecular Weight: 150.13
• Hs Code.: 2933990090
• Mol file: 115012-09-4.mol

Synonyms:5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI)

Chemical Property of 5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI)

Chemical Property:

• PSA: 65.71000
• LogP: -0.17370
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

7-Hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI)

There total 3 articles about 5H-Pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-7-hydroxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.1%

2,3-pyridinedicarboximide (4664-00-0,303983-78-0) → 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one (115012-09-4) + 5,6-dihydro-5-hydroxy-7H-pyrrolo<3,4-b>pyridin-7-one (115012-10-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; chloroform; at -20 ℃; for 30h;

DOI:10.1246/bcsj.60.4178

Reference yield:

2,3-pyridinedicarboximide (4664-00-0,303983-78-0) → 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one (115012-09-4)

Guidance literature:

With sodium tetrahydroborate; magnesium(II) perchlorate; In methanol; chloroform; at -20 ℃; for 0.5h; Yield given;

DOI:10.1246/bcsj.62.1205

Reference yield:

Pyridine-2,3-dicarboxylic acid (89-00-9) → 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one (115012-09-4) + 5,6-dihydro-5-hydroxy-7H-pyrrolo<3,4-b>pyridin-7-one (115012-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetamide; acetic anhydride / Reflux

2: sodium tetrahydroborate / chloroform; methanol / -20 °C

With acetamide; sodium tetrahydroborate; acetic anhydride; In methanol; chloroform;

DOI:10.1039/c6cc02002j

upstream raw materials:

2,3-pyridinedicarboximide

Pyridine-2,3-dicarboxylic acid

Downstream raw materials:

7-(4-Bromo-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one

7-(2-Bromo-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one

7-(3,4-Dimethoxy-phenyl)-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one

2-(hydroxymethyl)nicotinamide