3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

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Chemical Name:3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione
CAS No.:1271801-23-0
Molecular Formula:C₂₇H₂₄N₆O₂
Molecular Weight:464.527
Hs Code.:

Synonyms:3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

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Chemical Property of 3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

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Technology Process of 3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

There total 6 articles about 3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1271808-64-0
C₃₄H₃₀N₆O₄S

: 1271801-23-0
3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: With methanol; water; potassium carbonate; In methanol; water; at 65 ℃;

Reference yield:

: 1271808-46-8
C₃₂H₃₁N₅O₄S

: 1271801-23-0
3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

2: methanol / 12 h / 75 °C

3: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 75 °C

4: potassium carbonate; water; methanol / water; methanol / 65 °C

With methanol; dmap; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; water; acetonitrile;

Reference yield:

: 908334-19-0
3-(1-tert-butoxycarbonyl-3-piperidyl)benzoic acid

: 1271801-23-0
3-(3-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)phenylamino)-4-(phenylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.2: 4 h / 90 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

4.1: methanol / 12 h / 75 °C

5.1: dmap; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 75 °C

6.1: potassium carbonate; water; methanol / water; methanol / 65 °C

With hydrogenchloride; methanol; dmap; diphenyl phosphoryl azide; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water; toluene; acetonitrile;