(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Base Information

Chemical Name:(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)
CAS No.:1446416-89-2
Molecular Formula:C₅₀H₄₂N₂O₆S₃
Molecular Weight:863.091
Hs Code.:

Synonyms:(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

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Chemical Property of (2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

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Technology Process of (2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

There total 3 articles about (2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2799-07-7
S-trityl-L-cysteine

: 1446416-88-1
bis(succinimidyl) 2,3-thiophenedicarboxylate

: 1446416-89-2
(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1055/s-0032-1318407

Reference yield:

: 1451-95-2
thiophene-2,3-dicarboxylic acid

: 1446416-89-2
(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide / ethyl acetate; 1,4-dioxane / 8.25 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1318407

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1446416-89-2
(2R,2'R)-2,2'-((thiophene-2,3-dicarbonyl)bis(azanediyl))bis(3-(tritylthio)propanoic acid)

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 19 h / 20 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide / ethyl acetate; 1,4-dioxane / 8.25 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With n-butyllithium; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; hexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1318407