1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Base Information

Chemical Name:1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol
CAS No.:332077-60-8
Molecular Formula:C₂₉H₃₄O₇
Molecular Weight:494.585
Hs Code.:

Synonyms:1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Suppliers and Price of 1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

There total 5 articles about 1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 179942-57-5
1-bromo-2,3-dimethoxy-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)benzene

: 332077-60-8
1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Guidance literature:: 1-bromo-2,3-dimethoxy-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)benzene; With n-butyllithium; at -78 ℃;

3-methoxy-4-(phenylmethoxy)benzaldehyde; at -78 ℃;
DOI:10.1016/S0040-4039(00)02163-8

Reference yield: 77.0%

: 109-72-8,29786-93-4
n-butyllithium

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 179942-57-5
1-bromo-2,3-dimethoxy-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)benzene

: 332077-60-8
1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

: 4-(5,5-dimethyl-1,3-dioxan-2-yl)-1,2-dimethoxybenzene

: 1-butyl-5-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-dimethoxybenzene

Guidance literature:: n-butyllithium; 1-bromo-2,3-dimethoxy-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)benzene; In tetrahydrofuran; at -78 ℃; for 1h;

3-methoxy-4-(phenylmethoxy)benzaldehyde; In tetrahydrofuran; at -78 ℃; for 6h;
DOI:10.1021/jo0258960

Reference yield:

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 332077-60-8
1-(p-benzyloxy-m-methoxyphenyl)-1-(2,3-dimethoxy)-5-(5',5'-dimethyl-1',3'-dioxan-2'-yl)phenyl carbinol

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammonium iodide; NaOH / CH₂Cl₂; H₂O / 20 °C

2.1: 58 percent / p-TsOH / Heating

3.1: nBuLi / -78 °C

3.2: 77 percent / -78 °C

With sodium hydroxide; n-butyllithium; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; In dichloromethane; water;
DOI:10.1016/S0040-4039(00)02163-8