ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

Base Information

Chemical Name:ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate
CAS No.:448955-45-1
Molecular Formula:C₃₂H₃₁ClF₂N₂O₆S
Molecular Weight:645.124
Hs Code.:

Synonyms:ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

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Chemical Property of ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

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Technology Process of ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

There total 9 articles about ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83613-31-4
3-(allyloxy)-4-chlorophenol

: 448955-45-1
ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: K₂CO₃ / dimethylformamide / 100 °C

2.1: AcOH / CH₂Cl₂ / 20 °C

2.2: Na(OAc)3BH / CH₂Cl₂ / 20 °C

3.1: diisopropylethylamine / dimethylformamide / 100 °C

4.1: Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 20 °C

5.1: PPh₃; di-tert-butyl azodicarboxylate / tetrahydrofuran / 20 °C

6.1: aq. NH₄Cl; Fe / ethanol / 80 °C

7.1: pyridine / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; phenylsilane; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 5.1: Mitsunobu reaction;
DOI:10.1021/jm050205o

Reference yield:

: 448956-94-3
4-(3-allyloxy-4-chloro-phenoxy)-benzaldehyde

: 448955-45-1
ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: AcOH / CH₂Cl₂ / 20 °C

1.2: Na(OAc)3BH / CH₂Cl₂ / 20 °C

2.1: diisopropylethylamine / dimethylformamide / 100 °C

3.1: Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 20 °C

4.1: PPh₃; di-tert-butyl azodicarboxylate / tetrahydrofuran / 20 °C

5.1: aq. NH₄Cl; Fe / ethanol / 80 °C

6.1: pyridine / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; phenylsilane; iron; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;
DOI:10.1021/jm050205o

Reference yield:

: toluene-4-sulfonic acid 3-allyloxy-4-chloro-phenyl ester

: 448955-45-1
ethyl (2-chloro-5-{4-[((2,4-difluorobenzyl){2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. KOH / ethanol / 90 °C

2.1: K₂CO₃ / dimethylformamide / 100 °C

3.1: AcOH / CH₂Cl₂ / 20 °C

3.2: Na(OAc)3BH / CH₂Cl₂ / 20 °C

4.1: diisopropylethylamine / dimethylformamide / 100 °C

5.1: Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 20 °C

6.1: PPh₃; di-tert-butyl azodicarboxylate / tetrahydrofuran / 20 °C

7.1: aq. NH₄Cl; Fe / ethanol / 80 °C

8.1: pyridine / 20 °C

With pyridine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-tert-butyl-diazodicarboxylate; phenylsilane; iron; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Mitsunobu reaction;
DOI:10.1021/jm050205o