Technology Process of C35H36ClF2N4O8P
There total 8 articles about C35H36ClF2N4O8P which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C35H35ClF2N3O9P;
With
1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
With
ammonium bicarbonate;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2.89 g / diisopropylethylamine / CH2Cl2 / 20 h / -20 °C
2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C
2.2: 41 percent / tetrahydrofuran / 10 h / -78 °C
3.1: 83 percent / aq. LiOH / tetrahydrofuran
4.1: N-hydroxysuccinimide; diisopropylcarbodiimide / tetrahydrofuran / 1.5 h / 0 °C
4.2: 52 percent / NH4HCO3 / tetrahydrofuran / 20 h / 0 - 20 °C
With
lithium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm061146x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.25 h / -78 °C
1.2: 41 percent / tetrahydrofuran / 10 h / -78 °C
2.1: 83 percent / aq. LiOH / tetrahydrofuran
3.1: N-hydroxysuccinimide; diisopropylcarbodiimide / tetrahydrofuran / 1.5 h / 0 °C
3.2: 52 percent / NH4HCO3 / tetrahydrofuran / 20 h / 0 - 20 °C
With
lithium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; lithium hexamethyldisilazane; diisopropyl-carbodiimide;
In
tetrahydrofuran;
DOI:10.1021/jm061146x
