Technology Process of 1-Cyclopentene-1-carboxaldehyde, 3-methyl-, (S)- (9CI)
There total 5 articles about 1-Cyclopentene-1-carboxaldehyde, 3-methyl-, (S)- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) hydrogen, 5percent Pd/C / 1.) ethyl acetate/benzene, 50 psi, 14 H; 2.) pyridine, 0-5 deg C; room temperature overnight
2: 81 percent / 10N sodium hydroxide / methanol / 1 h / Heating
3: 86 percent / periodic acid / tetrahydrofuran / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h
4: 1.) piperidine 2.) glacial acetic acid / 1.) ether, 0 deg C, 2.5 h; 2.) ether, 0 deg C, room temperature 3 h
With
piperidine; sodium hydroxide; palladium on activated charcoal; hydrogen; acetic acid; periodic acid;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00222a035
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / 10N sodium hydroxide / methanol / 1 h / Heating
2: 86 percent / periodic acid / tetrahydrofuran / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h
3: 1.) piperidine 2.) glacial acetic acid / 1.) ether, 0 deg C, 2.5 h; 2.) ether, 0 deg C, room temperature 3 h
With
piperidine; sodium hydroxide; acetic acid; periodic acid;
In
tetrahydrofuran; methanol;
DOI:10.1021/ja00222a035
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 86 percent / periodic acid / tetrahydrofuran / 1.) 0 deg C, 10 min; 2.) room temperature, 1 h
2: 1.) piperidine 2.) glacial acetic acid / 1.) ether, 0 deg C, 2.5 h; 2.) ether, 0 deg C, room temperature 3 h
With
piperidine; acetic acid; periodic acid;
In
tetrahydrofuran;
DOI:10.1021/ja00222a035