3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

Base Information

Chemical Name:3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester
CAS No.:850479-52-6
Molecular Formula:C₇₄H₈₄O₁₆
Molecular Weight:1229.47
Hs Code.:

Synonyms:3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

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Chemical Property of 3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

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Technology Process of 3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

There total 6 articles about 3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 850479-51-5
3,5-bis[4-(tetrahydropyranyloxymethyl)benzyloxy]benzyl alcohol

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 850479-52-6
3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In acetone; for 12h; Heating;
DOI:10.1021/ma047375f

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 850479-52-6
3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. HCl / CH₂Cl₂ / 12 h / 20 °C

2: 82.1 percent / 18-crown-6; KI; K₂CO₃ / acetone / 13 h / Heating

3: 96.2 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 20 °C

4: 87 percent / iPr₂NEt; CBr₄; PPh₃ / tetrahydrofuran / 0.25 h / 20 °C

5: 90 percent / 18-crown-6; K₂CO₃ / acetone / 12 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/ma047375f

Reference yield:

: 850479-50-4
3,5-bis[4-(tetrahydropyranyloxymethyl)benzyloxy]benzyl alcohol

: 850479-52-6
3,5-bis-{3,5-bis-[4-(tetrahydro-pyran-2-yloxymethyl)-benzyloxy]-benzyloxy}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / iPr₂NEt; CBr₄; PPh₃ / tetrahydrofuran / 0.25 h / 20 °C

2: 90 percent / 18-crown-6; K₂CO₃ / acetone / 12 h / Heating

With 18-crown-6 ether; carbon tetrabromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; acetone;
DOI:10.1021/ma047375f