3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

Base Information

Chemical Name:3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester
CAS No.:1025700-72-4
Molecular Formula:C₂₀H₂₀N₂O₂S
Molecular Weight:352.457
Hs Code.:

Synonyms:3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

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Chemical Property of 3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

Chemical Property:

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Technology Process of 3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

There total 2 articles about 3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025700-46-2
5-bromo-4-isopropyl-thiazole

: 1025699-99-3
3-(5-methyl-pyridin-2-yl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester

: 1025700-72-4
3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 20 - 80 ℃; for 21h;

Reference yield:

: 1025700-04-2
3-iodo-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

: 1025700-72-4
3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 3 h / 80 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield: 95.0%

: 1025700-72-4
3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester

: 1025700-73-5
3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid

Guidance literature:: 3-(5-isopropyl-thiazol-4-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃;

With hydrogenchloride; water; pH=6 - 7;