(ALPHA-S)-N-METHYL-ALPHA-[[(2S)-2-PIPERIDINYLCARBONYL]AMINO]-1H-INDOLE-3-PROPANAMIDE

Base Information

Chemical Name:(ALPHA-S)-N-METHYL-ALPHA-[[(2S)-2-PIPERIDINYLCARBONYL]AMINO]-1H-INDOLE-3-PROPANAMIDE
CAS No.:875151-71-6
Molecular Formula:C₁₈H₂₄N₄O₂
Molecular Weight:328.414
Hs Code.:
Mol file:875151-71-6.mol

Synonyms:(S)-piperidine-2-carboxylic acid [(S)-2-(indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (ALPHA-S)-N-METHYL-ALPHA-[[(2S)-2-PIPERIDINYLCARBONYL]AMINO]-1H-INDOLE-3-PROPANAMIDE

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:

Useful:

Technology Process of (ALPHA-S)-N-METHYL-ALPHA-[[(2S)-2-PIPERIDINYLCARBONYL]AMINO]-1H-INDOLE-3-PROPANAMIDE

There total 4 articles about (ALPHA-S)-N-METHYL-ALPHA-[[(2S)-2-PIPERIDINYLCARBONYL]AMINO]-1H-INDOLE-3-PROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875151-70-5
(S)-1-CBZ-piperidine-2-carboxylic acid [(S)-2-(indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

: 875151-71-6
(S)-piperidine-2-carboxylic acid [(S)-2-(indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; for 2h; under 760.051 Torr;

Reference yield:

: 53708-63-7
(S)-2-amino-3-(1H-indol-3-yl)-N-methylpropanamide

: 875151-71-6
(S)-piperidine-2-carboxylic acid [(S)-2-(indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 17 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 53708-61-5
Z-Trp-NH-CH₃

: 875151-71-6
(S)-piperidine-2-carboxylic acid [(S)-2-(indol-3-yl)-1-methylcarbamoyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 1.5 h

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 17 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate;