Technology Process of 6-methyl-2-(pentafluorophenyl)quinoxaline
There total 2 articles about 6-methyl-2-(pentafluorophenyl)quinoxaline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; CyJohnPhos;
In
tert-butyl alcohol;
at 90 ℃;
for 12h;
Inert atmosphere;
sealed tube;
DOI:10.1021/ol201706t
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dmap; triethylamine / dichloromethane / 20 °C
2: potassium phosphate; palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; CyJohnPhos / tert-butyl alcohol / 12 h / 90 °C / Inert atmosphere; sealed tube
With
dmap; potassium phosphate; palladium(II) trifluoroacetate; 1-Adamantanecarboxylic acid; triethylamine; CyJohnPhos;
In
dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol201706t
- Guidance literature:
-
With
triethylsilane; tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 13h;
regioselective reaction;
Sealed tube;
Inert atmosphere;
DOI:10.1002/anie.201300400
