diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Base Information

Chemical Name:diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate
CAS No.:133719-58-1
Molecular Formula:C₂₅H₃₃N₇O₅
Molecular Weight:511.581
Hs Code.:

diethyl 4-<N-<2-(2,4-diamino-7H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Synonyms:diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

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Chemical Property of diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

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Technology Process of diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

There total 8 articles about diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10541-82-9
ethyl 4-(methylamino)benzoate

: 133719-58-1
diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / K₂CO₃, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 13 h / 80 °C

2: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

3: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

4: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

5: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

6: 32 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

7: aq. NaOH / methanol / 12 h / 60 °C

8: 1.) diphenylphosphoryl azide, 2.) Et₃N / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 72 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium hydroxide; borane-THF; diphenylphosphoranyl azide; hydrogen; iodine; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.43.256

Reference yield:

: 165900-79-8
methyl 4-crotonate

: 133719-58-1
diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

2: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

3: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

4: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

5: 32 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

6: aq. NaOH / methanol / 12 h / 60 °C

7: 1.) diphenylphosphoryl azide, 2.) Et₃N / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 72 h

With sodium hydroxide; borane-THF; diphenylphosphoranyl azide; hydrogen; iodine; sodium ethanolate; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.43.256

Reference yield:

: 133719-37-6
methyl 4-butyrate

: 133719-58-1
diethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoyl-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

2: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

3: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

4: 32 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

5: aq. NaOH / methanol / 12 h / 60 °C

6: 1.) diphenylphosphoryl azide, 2.) Et₃N / 1.) DMF, 0 deg C, 15 min, 2.) DMF, RT, 72 h

With sodium hydroxide; borane-THF; diphenylphosphoranyl azide; iodine; sodium ethanolate; sodium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.43.256