6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine

Base Information

• Chemical Name: 6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine
• CAS No.: 943622-24-0
• Molecular Formula: C₂₀H₁₅ClN₆O₅S
• Molecular Weight: 486.895

Synonyms:6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine

Chemical Property of 6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine

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Technology Process of 6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine

There total 1 articles about 6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

6-chloropurine (87-42-3) + 1-(2-nitrobenzenesulfonyl)-3-methoxy-1,2,3,5-tetrahydro-4,1-benzoxazepine (817160-16-0) → 6-chloro-9-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine + 6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine (943622-24-0) + 6-chloro-9-{2-[N-(2-hydroxymethylphenyl)-2-nitrobenzenesulfonamide]-1-methoxyethyl}-9H-purine + 6-chloro-7-{2-[N-(2-hydroxymethylphenyl)-2-nitrobenzenesulfonamide]-1-methoxyethyl}-7H-purine

Guidance literature:

With chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; acetonitrile; at 0 - 50 ℃; Further byproducts.;

DOI:10.1016/j.tet.2007.03.155

Reference yield: 89.0%

6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine (943622-24-0) → 6-phenylthio-7-(1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)-7H-purine

Guidance literature:

With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

DOI:10.1016/j.tet.2007.03.155

Reference yield: 61.0%

6-chloro-7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-7H-purine (943622-24-0) + thiophenol (108-98-5) → 7-[1-(2-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-6-phenylthio-7H-purine

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

DOI:10.1016/j.tet.2007.03.155

upstream raw materials:

6-chloropurine

1-(2-nitrobenzenesulfonyl)-3-methoxy-1,2,3,5-tetrahydro-4,1-benzoxazepine

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