1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate
• CAS No.: 934584-70-0
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.389

Synonyms:1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate

Chemical Property of 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate

There total 1 articles about 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-2-methyl-5-{4-[(phenylmethyl)oxy]phenyl}-1-pyrrolidinecarboxylate (934584-69-7) → 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate (934584-70-0)

Guidance literature:

With hydrogen; palladium on activated carbon; In methanol; for 5h; under 760.051 Torr;

Reference yield: 72.0%

o-fluorobenzyl bromide (446-48-0) + 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate (934584-70-0) → 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-methyl-1-pyrrolidinecarboxylate (934584-71-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-hydroxyphenyl)-2-methyl-1-pyrrolidinecarboxylate (934584-70-0) + 2-fluorobenzonitrile (394-47-8) → 1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-{4-[(2-cyanophenyl)oxy]phenyl}-2-methyl-1-pyrrolidinecarboxylate (934584-73-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-2-methyl-5-{4-[(phenylmethyl)oxy]phenyl}-1-pyrrolidinecarboxylate

Downstream raw materials:

1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-2-methyl-1-pyrrolidinecarboxylate

1,1-dimethylethyl (2S,5R)-2-(aminocarbonyl)-5-{4-[(2-cyanophenyl)oxy]phenyl}-2-methyl-1-pyrrolidinecarboxylate

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