8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Name:8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one
CAS No.:1352130-61-0
Molecular Formula:C₂₇H₃₀N₆O₃S
Molecular Weight:518.64
Hs Code.:

Synonyms:8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Property of 8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

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Technology Process of 8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

There total 5 articles about 8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1232030-40-8
6-bromo-8-ethyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1352130-61-0
8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 140 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 211244-81-4
2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352130-61-0
8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

2.2: 1.5 h / 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C

4.1: 3 h / 120 °C

5.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; N-Bromosuccinimide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 5.1: Suzuki Coupling;

Reference yield:

: 352328-87-1
6-bromo-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1352130-61-0
8-ethyl-6-(4-methanesulfonyl-phenyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

1.2: 1.5 h / 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C

3.1: 3 h / 120 °C

4.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki Coupling;