1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

Base Information

Chemical Name:1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline
CAS No.:135018-76-7
Molecular Formula:C₂₈H₂₁N
Molecular Weight:371.481
Hs Code.:

1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropa<c>isoquinoline

Synonyms:1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

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Chemical Property of 1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

There total 12 articles about 1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 135018-76-7
1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux

2: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

4: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

5: 80 percent / dimethylformamide / Ambient temperature

6: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

7: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

8: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 20 min

9: thionyl chloride / diethyl ether / Heating

10: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C / other N-<2-(substituted phenyl)-6-(substituted aryl)benzyl>benzimidoyl chlorides, competing cyclisation on to the substituent in 2 position and in 6 position, other solvent: DMF

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; Perbenzoic acid; potassium tert-butylate; hydrogen; sodium carbonate; hydrazine hydrate; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 107622-50-4
2-nitro-6-phenyltoluene

: 135018-76-7
1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

3: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

4: 80 percent / dimethylformamide / Ambient temperature

5: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

6: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

7: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 20 min

8: thionyl chloride / diethyl ether / Heating

9: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C / other N-<2-(substituted phenyl)-6-(substituted aryl)benzyl>benzimidoyl chlorides, competing cyclisation on to the substituent in 2 position and in 6 position, other solvent: DMF

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; Perbenzoic acid; potassium tert-butylate; hydrogen; sodium carbonate; hydrazine hydrate; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 603-83-8
3-nitro-o-tolylamine

: 135018-76-7
1H-1,1a,4-triphenyl-1a,7b-dihydrocyclopropaisoquinoline

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaNO₂, HBr, 2.) CuBr

2: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux

3: 100 percent / hydrogen / Pd/C / ethanol / 1810.02 Torr

5: 99 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 2 h / Heating

6: 80 percent / dimethylformamide / Ambient temperature

7: 92 percent / hydrazine hydrate / methanol / 1 h / Heating

8: 73 percent / sodium carbonate / CH₂Cl₂ / Ambient temperature

9: 1.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, 2.) sodium carbonate / 1.) 1,2-dimethoxyethane, 20 min, 2.) 1,2-dimethoxyethane, water, reflux, 20 min

10: thionyl chloride / diethyl ether / Heating

11: potassium tert-butoxide / tetrahydrofuran / 0 - 20 °C / other N-<2-(substituted phenyl)-6-(substituted aryl)benzyl>benzimidoyl chlorides, competing cyclisation on to the substituent in 2 position and in 6 position, other solvent: DMF

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; Perbenzoic acid; potassium tert-butylate; hydrogen bromide; hydrogen; sodium carbonate; hydrazine hydrate; copper(I) bromide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;