3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine

Base Information

• Chemical Name: 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine
• CAS No.: 494800-89-4
• Molecular Formula: C₃₁H₃₉NO₆
• Molecular Weight: 521.654

Synonyms:3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine

Chemical Property of 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine

There total 2 articles about 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 3,5,6-tri-O-benzyl-2-O-(3-tert-butoxycarbonylaminopropyl)-α,β-D-glucofuranoside (494800-81-6) → 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine (494800-89-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo025978o

Reference yield:

methyl 3,5,6-tri-O-benzyl-α,β-D-glucofuranoside (55902-93-7) → 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine (494800-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / NaH / dimethylformamide / 0 - 20 °C

2: 86 percent / CF₃COOH / CH₂Cl₂ / 1 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo025978o

Reference yield:

bromoacetic acid methyl ester (96-32-2) + 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine (494800-89-4) → methyl 3,5,6-tri-O-benzyl-2-O-{3-[N,N-bis(methoxycarbonylmethyl)amino]propyl}-α,β-D-glucofuranoside (494800-95-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; Heating;

DOI:10.1021/jo025978o

upstream raw materials:

methyl 3,5,6-tri-O-benzyl-2-O-(3-tert-butoxycarbonylaminopropyl)-α,β-D-glucofuranoside

methyl 3,5,6-tri-O-benzyl-α,β-D-glucofuranoside

Downstream raw materials:

methyl 3,5,6-tri-O-benzyl-2-O-{3-[N,N-bis(methoxycarbonylmethyl)amino]propyl}-α,β-D-glucofuranoside

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 494800-89-4 3-[(3R,4S,5R)-4-Benzyloxy-5-((R)-1,2-bis-benzyloxy-ethyl)-2-methoxy-tetrahydro-furan-3-yloxy]-propylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send